Spectrin



Spectrin forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of alpha1 and beta1 monomers. In invertebrates there are SPT alpha, beta and betaH. In vertebrates there are SPT alpha1 (SPTA1), alpha2 (SPTA2) and beta1 (SPTB1) to beta5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. The images at the left and at the right correspond to one representative Spectrin, i.e. the crystal structure of human Spectrin (3lbx).

SPTA1
3lbx – hSPTA1+hSPTB1 – human

3i9q, 2rot, 2pqh, 2oaw, 2nuz, 1u06 - cSPTA1 SH3 domain – chicken

2jm8, 2jm9, 2cdt, 2f2v, 2f2w, 2f2x - cSPTA1 SH3 domain (mutant)

2jma, 2jmc - cSPTA1 SH3 domain (mutant)+P41 peptide

2rmo, 1neg, 1m8m - cSPTA1 SH3 domain – NMR

SPTA2
3f31 – hSPTA2 tetramerization domain

1qkw – cSPTA2 SH3 domain (mutant)

2fot - SPTA2+calmodulin – Bos taurus

3fb2 – hSPTA2 repeats 15-16

SPTA
1uue, 1e7o, 1g2b, 1aey, 1tuc, 1tud - cSPTA SH3 domain (mutant) – NMR

1e6g, 1e6h, 1hd3, 1qkx, 1pwt, 1bk2, 1shg - cSPTA SH3 domain (mutant)

1u4q – cSPTA repeats 15-17

1u5p - cSPTA repeats 15-16

1cun - cSPTA repeats 16-17

1aj3 - cSPTA repeat 16 - NMR

1owa - hSPTA tetramerization domain – NMR

1h8k, 3ngp, 3m0p, 3m0q, 3m0r, 3m0s, 3m0t, 3m0u – cSPTA SH3 domain (mutant)

2kr3 - cSPTA SH3 domain

SPTB1
3bkt, 3kbu - hSPTB1+ankyrin

3f57, 3edu - hSPTB1 ankyrin binding domain

1s35 – hSPTB1 repeats 8-9

SPTB2
3edv – hSPTB2 repeats 14-16

SPTB3
1wyq – hSPTB3 CH domain – NMR

1wjm – hSPTB3 – NMR

SPTB
1bkr, 1aa2 – hSPTB CH domain

1mph – SPTB Pleckstrin Homology domain – NMR

1dro - mSPTB PH domain – NMR – mouse

1btn – mSPTB+inositol phosphate

2spc – SPT fragment - Drosophila